Novel preparation techniques used in new dosage form of dipyridamole:research advances / 国际药学研究杂志

ABSTRACT

Dipyridamole,a widely used drug in clinics that inhibits platelet agregation,also shows great potential for anti-vi- ral and anti-tumor effect in recent years. However,with its poor and pH-dependent solubility as well as the narrow absorption window in the gastrointestinal tract,the conventional oral dosage forms have problems of low bioavailability,high inter-subject variability and insufficient drug efficacy. The novel drug delivery systems based on solid dispersion,gastro-floating,microenvironmental pH-modifica- tion,drug-protein complex and nanoparticle technologies are the effective methods to enhance oral drug absorption. In this paper we re- view the recent advances in novel dosage form and preparation technology of dipyridamole,to provide references for development of novel preparation with good safety,therapeutic efficacy and patient compliance.