Glycosides from roots of Isatis indigotica / 中草药

ABSTRACT

Objective: To study the glycosides from the roots of Isatis indigotica. Methods: The chemical components were isolated and purified by silica gel, Sephadex LH-20, ODS C18 gel, and semi preparative-HPLC chromatographic techniques while the structures were deduced by NMR, MS and IR spectral data analysis. Results: A total of 12 glycosides were obtained and elucidated as isatindigoside C (1), epiprogoitrin (2), progoitrin (3), o-aminobenzoic acid 7-O-β-D-glucopyranosyl ester (4), 2’-O-methyladenosine (5), 2-methoxyphenyl β-D-glucopyranoside (6), coniferin (7), syringin (8), cis-coniferin (9), cis-syringin (10), corchoionoside C (11), and cannabiside D (12). Conclusion: Compound 1 is a new indole alkaloid glycoside which named as isatindigoside C, while compounds 5-7 and 9-12 are isolated from the plant for the first time.