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“Preventing transform when sickness”——Regulating pre-metastasis niche to prevent tumor metastasis / 中草药
Article ي Zh | WPRIM | ID: wpr-851498
المكتبة المسؤولة: WPRO
ABSTRACT
Metastasis is the leading cause of cancer-related death. Pre-metastatic niche formation is the contributing factor of tumor metastasis. Traditional Chinese medicine (TCM) has a curative effect on metastasis and cancer recurrence in clinic. Modern pharmacological studies have shown that China meteria medica (CMM) can inhibit tumor metastasis by affecting tumor secretion, preventing recruitment of immune suppressive cells, and influencing anti-inflammatory polarization of matrix components in certain tissues. The regulation of CMM has the characteristics of multi-target, minor effect, and bidirection, It may play a integrate role with multi-factor and minor effect in regulating tumor-related gene expression or gene-gene combination by influencing regulating tumor-related functional gene networks. This is consistent with the research strategy of taking signal transduction dynamic network as drug target. Therefore, the prevention and treatment of pre-metastatic niche formation via TCM is an effective research strategy. This review summarizes the current research progress on regulating pre-metastasis niche by CMM, and provides a theoretical basis for the future research of TCM to prevent tumor metastasis.
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النص الكامل: 1 الفهرس: WPRIM اللغة: Zh مجلة: Chinese Traditional and Herbal Drugs السنة: 2018 نوع: Article
النص الكامل: 1 الفهرس: WPRIM اللغة: Zh مجلة: Chinese Traditional and Herbal Drugs السنة: 2018 نوع: Article