Research progress in effects of active component from Chinese materia medica on β-amyloid in Alzheimer's disease / 中草药

ABSTRACT

Abnormal deposit of β-amyloid (Aβ) is closely related with the genesis and development of Alzheimer's disease (AD). Based on Aβ for target, looking for potential therapeutic agents in the treatment of AD is a hotspot of current research. Chinese materia medica (CMM) has small toxic side effect, with multi-target, multi-channel, and multi-link effect of functions and characteristics. According to vast information from literatures in the last decade, the composition of CMM can reduce Aβ production, promote Aβ clearance, and antagonize its toxicity, thus easing the development of AD. This article summarizes and reviews the research progress on Aβ targeting CMM, in hopes of providing a reference for further study in the future prevention of AD.