Studies on chemical constituents in Guizhi Fuling Capsule (V) / 中草药

ABSTRACT

To investigate the chemical constituents from the ethyl acetate and n-butanol extact of Guizhi Fuling Capsule. The compounds were isolated by chromatography on silica gel, Sephdex LH-20 columns, and prep-HPLC. The chemical structures were identified by NMR methods, respectively. Eleven compounds were isolated from the ethyl acetate extact. They were identified as benzoylpaeoniflorin (1), albiflorin R1 (2), paeonidanin A (3), 4-methylbenzoylpaeoniflorin (4), paeonidanin B (5), 4-O-methylgalloylpaeoniflorin (6), and paeoniflorin B (7). Four compounds were isolated from the n-butanol extact and were identified as isomaltopaeoniflorin (8), paeoniflorin (9), oxypaeoniflorin (10), and albiflorin (11). Compounds 1-8 are isolated from Guizhi Fuling Capsula for the first time, and compounds 1-11 belong to the category of peaoniflorin.