Chemical constituents from Cardamine leucantha / 中草药

ABSTRACT

Objective: To investigate the chemical constituents in the whole herbs of Cardamine leucantha. Methods: The chemical constituents were isolated and purified via silica gel, polyamide, D-101 macroperous resin, and Sephadex LH-20 column chromatography. Their structures were determined on the basis of spectral analysis and physicochemical properties. Results: Fourteen compounds were isolated and identified, covering three simple indoles indole-3-carboxylic acid (1), 6-hydroxyindole-3-carboxylic acid (2), and 6-hydroxyindole-3-carboxylic acid-6-O-β-D-glucopyranoside (3); two coumarins esculetin (4) and esculin (5); seven steroids 3-O-(p-coumaroyl)-β-sitosterol (6), β-sitosterol (7), 5α, 8α-epidioxyergosta-6, 22-dien-3β-ol (8), 5α, 8α-epidioxyergosta-6, 9 (11), 22-trien-3β-ol (9), sitost-5-ene-3β, 7α-diol (10), β-sitosteryl-3β-glucopyranoside-6'-O-palmitate (11), and daucosterol (12); and two phenolic compounds p-hydroxybenzoic acid (13) and vanillic acid (14). Conclusion: All the compounds are isolated from the plants in Cardamine L. for the first time.