Genetic Variants in the Wnt Signaling Pathway Are Not Associated with Survival Outcome of Non-Small Cell Lung Cancer in a Korean Population
Journal of Korean Medical Science
; : 463-466, 2016.
Article
ي En
| WPRIM
| ID: wpr-85712
المكتبة المسؤولة:
WPRO
ABSTRACT
Recently, genetic variants in the WNT signaling pathway have been reported to affect the survival outcome of Caucasian patients with early stage non-small cell lung cancer (NSCLC). We therefore attempted to determine whether these same WNT signaling pathway gene variants had similar impacts on the survival outcome of NSCLC patients in a Korean population. A total of 761 patients with stages I-IIIA NSCLC were enrolled in this study. Eight variants of WNT pathway genes were genotyped and their association with overall survival and disease-free survival were analyzed. None of the eight variants were significantly associated with overall survival or disease-free survival. There were no differences in survival outcome after stratifying the subjects according to age, gender, smoking status, and histological type. These results suggest that genetic variants in the WNT signaling pathway may not affect the survival outcome of NSCLC in a Korean population.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Smoking
/
Demography
/
Carcinoma, Non-Small-Cell Lung
/
Disease-Free Survival
/
Polymorphism, Single Nucleotide
/
Asian People
/
Kaplan-Meier Estimate
/
Republic of Korea
/
Wnt Signaling Pathway
/
Genotype
المحددات:
Aged
/
Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2016
نوع:
Article