Deformation mechanisms and compactibility of directly compressible excipients using induction tablet press / 中国药学杂志

ABSTRACT

OBJECTIVE: To study deformation behaviors of directly compressed materials using induction tableting machine. METHODS: Eighteen types of materials, which were widely used in tablet production, were selected and compressed. Their deformation behaviors and compactability were investigated by applying classic methods involving compression models, mechanical energy and elastic stretch. RESULTS: Cellulose and copovidone with lower Py and E were ranked in high TS interval; starches with lower Py, high FES and Esp, and larger E values than cellulose, were ranked in inferior TS interval; polyols and lactose materials resembling cellulose powders in appearance of Esp and Py, were of higher E values than that of the latter and mostly ranked in intermediate interval; mineral materials with highest Py and E were ranked in inferior TS interval. CONCLUSION: Copovidone and cellulose derivatives display good plastic deformation and compactability whereas Ac-Di-Sol SD711 mainly deform elastically; starch derivatives primarily undergo plastic deformation during compaction but with high FES and relatively poor compactability; polyols and lactose materials exhibit brittle characteristics during loading and the former consolidating better; mineral materials show great resistance to break and deform and have relatively high elastic recovery.