Research progress about detection methods of drug-induced nephrotoxicity biomarkers / 中国药学杂志

ABSTRACT

OBJECTIVE: To review the research status and progress about detection methods of drug-induced nephrotoxicity biomarkers in recent years. METHODS: By looking up papers and books of preclinical and clinical research on nephrotoxicity biomarkers and related detection methods, we made description and summary on different detection methods and their practical application. RESULTS AND CONCLUSION: Multiplex assays such as Luminex xMAP have been used more frequently, they are faster and more efficient than ELISA and Western blot. However, multiplex assays still need to be compared and verified in the practical use. In addition, methods which are independent of antigen-antibody reaction and which are based on toxicogenomics have been developed. These new detection methods will greatly improve the discovery and confirmation of new nephrotoxicity biomarkers.