Advances in the correlation between HDAC8 gene and idiopathic pulmonary fibrosis / 国际儿科学杂志

ABSTRACT

In recent years, the incidence of idiopathic pulmonary fibrosis has been increasing year by year.Although traditional drugs have been shown to be effective in preventing process of pulmonary fibrosis, their side effects are high and application is limited.Cell, cytokine, and epithelial-mesenchymal transition all participate in the process of pulmonary fibrosis, and HDAC8 also plays an important role in these related processes.The researchers found that HDAC8 contributes to pulmonary fibrosis, and that HDAC8 inhibitors have the potential to treat IPF and other fibrotic lung diseases.In this paper, the research progress of the relationship between HDAC8 gene and idiopathic pulmonary fibrosis in recent years is reviewed.