Clinical significance of changes of inflammatory factors, AOPP, Hcy, VCAM-1 expression and pregnancy outcome in patients with gestational diabetes mellitus / 中国基层医药

ABSTRACT

Objective:To investigate the expression of inflammatory factors, advanced oxidation protein products (AOPP), homocysteine (Hcy), vascular cell adhesion molecule 1 (VCAM-1) and the clinical significance of pregnancy outcome in patients with gestational diabetes.Methods:From January 2019 to January 2020, 103 cases of gestational diabetes in Taizhou Hospital of Zhejiang province were selected as observation group, and 87 normal pregnant women in Taizhou Hospital of Zhejiang province from January 2019 to January 2020 were selected as control group.The fasting blood glucose (FPG) and fasting insulin (FINS) were measured by automatic biochemical analyzer.The levels of tumor necrosis factor-α(TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), AOPP and VCAM-1 were measured by enzyme-linked immunosorbent assay (ELISA). The Hcy level was measured by circulating enzyme method.Results:The FPG [(8.34±1.25)mmol/L] and FINS [(9.75±0.89)U/L] in the observation group were higher than those in the control group [(4.89±0.67)mmol/L and (5.93±0.45)U/L] ( t=23.088, 36.297, all P<0.05). The serum levels of TNF-α [(21.63±3.25)ng/L], hs-CRP [(6.34±1.29)mg/L], IL-6 [(147.32±28.39)ng/L] in the observation group were higher than those in the control group [(8.72±1.84)ng/L, (2.17±0.73)mg/L and (87.96±12.41)ng/L] ( t=32.861, 26.744, 18.091, all P<0.05). The serum levels of AOPP [(53.21±9.89)μg/L], Hcy [(11.23±1.36)μmol/L] and VCAM-1 [(94.27±15.46)μg/L] in the observation group were higher than those in the control group [(25.48±6.18)μg/L, (8.41±1.28)μmol/L and (62.18±6.52)μg/L] ( t=22.674, 14.627, 18.047, all P<0.05). The incidence of adverse pregnancy outcome in the observation group (29.13%) was lower than that in the control group (4.60%) (χ 2=19.313, P<0.05). Conclusion:The patients with gestational diabetes have obvious inflammatory reaction, higher serum levels of AOPP, Hcy and VCAM-1, and poor pregnancy outcome.