Effect of Vitapex paste on chronic periapical periodontitis and its influence on serum TNF-α, C-reactive protein and IL-6 / 中国基层医药

ABSTRACT

Objective:To investigate the effect of Vitapex paste on chronic periapical periodontitis and its influence on serum TNF-α, C-reactive protein(CRP) and IL-6.Methods:From January 2018 to June 2019, 120 patients with chronic periapical periodontitis admitted to Dajiangdong Hospital in Hangzhou were randomly divided into observation group (60 cases) and control group (60 cases) according to the random digital table method.The patients in the observation group were treated with Vitapex paste, while the patients in the control group were treated with calcium hydroxide paste.The changes of serum TNF-α, CRP and IL-6, the changes of the number of bacterial colonies in the root canal before and 6 months after operation, and the therapeutic effect at 6 months after operation were compared.Results:The patients with no pain or mild pain in the observation group at 7 days after operation (30.00%) was more than that in the control group (10.00%) (χ 2=7.500, P<0.05). The levels of TNF-α [(4.68±1.20)μg/L], CRP [(4.35±0.79)mg/L] and IL-6 [(2.15±0.54)μg/L] in the observation group were lower than those in the control group [(7.89±1.42)μg/L, (8.19±1.32)mg/L and (4.58±1.02)μg/L] ( t=13.472, 19.335 and 16.309, all P<0.05). At 6 months after operation, the number of bacterial colonies in the root canal of the observation group [(4.26±0.35)CFU] was lower than that of the control group [(9.72±2.43)CFU]( t=17.227, P<0.05). The total effective rate of the observation group (90.00%) was higher than that of the control group (73.33%) (χ 2=5.566, P<0.05). Conclusion:Vitapex paste is effective in the treatment of chronic periapical periodontitis, and can reduce the serum levels of TNF-α, CRP and IL-6.