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Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-gamma Agonist, Restores Alveolar and Pulmonary Vascular Development in a Rat Model of Bronchopulmonary Dysplasia
Yonsei med. j ; Yonsei med. j;: 99-106, 2014.
Article ي En | WPRIM | ID: wpr-86935
المكتبة المسؤولة: WPRO
ABSTRACT
PURPOSE: We tested whether rosiglitazone (RGZ), a peroxisome proliferator-activated receptor-gamma agonist, can restore alveolar development and vascular growth in a rat model of bronchopulmonary dysplasia (BPD). MATERIALS AND METHODS: A rat model of BPD was induced through intra-amniotic delivery of lipopolysaccharide (LPS) and postnatal hyperoxia (80% for 7 days). RGZ (3 mg/kg/d, i.p.) or vehicle was given daily to rat pups for 14 days. This model included four experimental groups: No BPD+vehicle (V), No BPD+RGZ, BPD+V, and BPD+RGZ. On D14, alveolarization, lung vascular density, and right ventricular hypertrophy (RVH) were evaluated. RESULTS: Morphometric analysis revealed that the BPD+RGZ group had significantly smaller and more complex airspaces and larger alveolar surface area than the BPD+V group. The BPD+RGZ group had significantly greater pulmonary vascular density than the BPD+V group. Western blot analysis revealed that significantly decreased levels of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 by the combined exposure to intra-amniotic LPS and postnatal hyperoxia were restored by the RGZ treatment. RVH was significantly lesser in the BPD+RGZ group than in the BPD+V group. CONCLUSION: These results suggest that RGZ can restore alveolar and pulmonary vascular development and lessen pulmonary hypertension in a rat model of BPD.
الموضوعات
Key words
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Vasodilator Agents / Bronchopulmonary Dysplasia / Immunohistochemistry / Rats, Sprague-Dawley / Thiazolidinediones / PPAR gamma / Hypertension, Pulmonary / Lung المحددات: Animals اللغة: En مجلة: Yonsei med. j السنة: 2014 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Vasodilator Agents / Bronchopulmonary Dysplasia / Immunohistochemistry / Rats, Sprague-Dawley / Thiazolidinediones / PPAR gamma / Hypertension, Pulmonary / Lung المحددات: Animals اللغة: En مجلة: Yonsei med. j السنة: 2014 نوع: Article