MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 8-19, 2020.
Article
ي En
| WPRIM
| ID: wpr-877973
المكتبة المسؤولة:
WPRO
ABSTRACT
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, placing an increasing burden on human health. NAFLD is a complex multifactorial disease involving genetic, metabolic, and environmental factors. It is closely associated with metabolic syndrome, obesity, and type 2 diabetes, of which insulin resistance is the main pathophysiological mechanism. Over the past few decades, investigation of the pathogenesis, diagnosis, and treatments has revealed different aspects of NAFLD, challenging the accuracy of definition and therapeutic strategy for the clinical practice. Recently, experts reach a consensus that NAFLD does not reflect the current knowledge, and metabolic (dysfunction) associated fatty liver disease (MAFLD) is suggested as a more appropriate term. The new definition puts increased emphasis on the important role of metabolic dysfunction in it. Herein, the shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy of the newly defined MAFLD, as compared with the formerly defined NAFLD, are reviewed for updating our understanding.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Insulin Resistance
/
Metabolic Syndrome
/
Diabetes Mellitus, Type 2
/
Non-alcoholic Fatty Liver Disease
/
Obesity
نوع الدراسة:
Diagnostic_studies
/
Screening_studies
المحددات:
Humans
اللغة:
En
مجلة:
Chinese Medical Journal
السنة:
2020
نوع:
Article