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Research Progress on Role and Mechanism of Elabela in Organ Fibrosis / 中国医学科学院学报
Article ي Zh | WPRIM | ID: wpr-878732
المكتبة المسؤولة: WPRO
ABSTRACT
Elabela is a newly discovered peptide in recent years.It is the endogenous ligand of Apelin receptor(APJ)and plays an important role in embryonic development and adult organs.Elabela-APJ axis is closely related to organ fibrosis.Elabela can protect the functions of heart and kidney by antagonizing renin-angiotensin system and regulating blood pressure.In addition,it can prevent kidney and heart fibrosis by down-regulating the expression of fibrosis and inflammatory factors.However,there is a positive correlation between the level of Elabela and the degree of liver fibrosis,suggesting that Elabela may play a role in promoting liver fibrosis.This review aims to explore the role of Elabela-APJ axis in renal fibrosis,cardiac fibrosis,and liver fibrosis,and to provide a new therapeutic target for organ fibrosis.
الموضوعات
Key words
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Blood Pressure / Fibrosis / Peptide Hormones / Apelin / Apelin Receptors المحددات: Female / Humans / Pregnancy اللغة: Zh مجلة: Acta Academiae Medicinae Sinicae السنة: 2021 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Blood Pressure / Fibrosis / Peptide Hormones / Apelin / Apelin Receptors المحددات: Female / Humans / Pregnancy اللغة: Zh مجلة: Acta Academiae Medicinae Sinicae السنة: 2021 نوع: Article