Clinical effect and mechanism of total glucosides of paeony in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis: a prospective randomized controlled study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 49-54, 2021.
Article
ي Zh
| WPRIM
| ID: wpr-879808
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To study the clinical effect and mechanism of total glucosides of paeony (TGP) in the adjuvant therapy for children with Henoch-Schönlein purpura nephritis (HSPN).@*METHODS@#Sixty-four HSPN children with moderate proteinuria were divided into a TGP treatment group (@*RESULTS@#Compared with the healthy children before treatment, the children with HSPN had higher proportion of Tfh cells and expression levels of IL-21 and IL-4 (@*CONCLUSIONS@#TGP has a marked clinical effect in the treatment of HSPN and can reduce the inflammatory response of the kidney and exert a protective effect on the kidney by inhibiting the proliferation of Tfh cells and downregulating the expression of IL-21 and IL-4 in plasma.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
IgA Vasculitis
/
Prospective Studies
/
Paeonia
/
Glucosides
/
Nephritis
نوع الدراسة:
Clinical_trials
/
Observational_studies
المحددات:
Child
/
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Contemporary Pediatrics
السنة:
2021
نوع:
Article