Association between maternal reduced folate carrier gene polymorphisms and congenital heart disease in offspring: a case-control study / 中国当代儿科杂志
Zhongguo dangdai erke zazhi
; Zhongguo dangdai erke zazhi;(12): 547-554, 2021.
Article
ي Zh
| WPRIM
| ID: wpr-879892
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To study the association between maternal reduced folate carrier (@*METHODS@#A hospital-based case-control study was conducted. The mothers of 683 infants with CHD who attended the Department of Cardiothoracic Surgery, Hunan Children's Hospital, from November 2017 to March 2020 were enrolled as the case group. The mothers of 740 healthy infants without any deformity who attended the hospital during the same period of time were enrolled as the control group. A questionnaire survey was performed to collect the exposure data of subjects. Venous blood samples of 5 mL were collected from the mothers for genetic polymorphism detection. A multivariate logistic regression analysis was used to evaluate the association of @*RESULTS@#After control for confounding factors, the multivariate logistic regression analysis showed that maternal @*CONCLUSIONS@#Maternal
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Case-Control Studies
/
Risk Factors
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Reduced Folate Carrier Protein
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Genotype
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Heart Defects, Congenital
نوع الدراسة:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
المحددات:
Child
/
Female
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Humans
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Infant
اللغة:
Zh
مجلة:
Zhongguo dangdai erke zazhi
السنة:
2021
نوع:
Article