Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 599-602, 2021.
Article
ي En
| WPRIM
| ID: wpr-888689
المكتبة المسؤولة:
WPRO
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has occasioned worldwide alarm. Globally, the number of reported confirmed cases has exceeded 84.3 million as of this writing (January 2, 2021). Since there are no targeted therapies for COVID-19, the current focus is the repurposing of drugs approved for other uses. In some clinical trials, antiviral drugs such as remdesivir (Grein et al., 2020), lopinavir/ritonavir (LPV/r) (Cao et al., 2020), chloroquine (Gao et al., 2020), hydroxychloroquine (Gautret et al., 2020), arbidol (Wang et al., 2020), and favipiravir (Cai et al., 2020b) have shown efficacy in COVID-19 patients. LPV/r combined with arbidol, which is the basic regimen in some regional hospitals in China including Zhejiiang Province, has shown antiviral effects in COVID-19 patients (Guo et al., 2020; Xu et al., 2020). A retrospective cohort study also reported that this combination therapy showed better efficacy than LPV/r alone for the treatment of COVID-19 patients (Deng et al., 2020).
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Retrospective Studies
/
Ritonavir
/
Drug Interactions
/
Drug Therapy, Combination
/
Lopinavir
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SARS-CoV-2
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COVID-19
/
Indoles
نوع الدراسة:
Observational_studies
المحددات:
Animals
اللغة:
En
مجلة:
Journal of Zhejiang University. Science. B
السنة:
2021
نوع:
Article