Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma / 国际口腔科学杂志·英文版
International Journal of Oral Science
; (4): 26-26, 2021.
Article
ي En
| WPRIM
| ID: wpr-888703
المكتبة المسؤولة:
WPRO
ABSTRACT
Methyltransferase like 13 (METTL13), a kind of methyltransferase, is implicated in protein binding and synthesis. The upregulation of METTL13 has been reported in a variety of tumors. However, little was known about its potential function in head and neck squamous cell carcinoma (HNSCC) so far. In this study, we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level. Increased METTL13 was negatively associated with clinical prognosis. And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro. Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail, the key transcription factor in EMT, hence regulating the progression of EMT. Furthermore, Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes. Altogether, our study had revealed the oncogenic role of METTL13 in HNSCC, and provided a potential therapeutic strategy.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Squamous Cell Carcinoma of Head and Neck
/
Head and Neck Neoplasms
نوع الدراسة:
Prognostic_studies
المحددات:
Humans
اللغة:
En
مجلة:
International Journal of Oral Science
السنة:
2021
نوع:
Article