A Case of Sweet Syndrome Induced by Bortezomib Rechallenge / 대한피부과학회지
Korean Journal of Dermatology
; : 299-302, 2021.
Article
ي En
| WPRIM
| ID: wpr-894304
المكتبة المسؤولة:
WPRO
ABSTRACT
Sweet syndrome is characterized by fever, tender, erythematous skin lesions, neutrophilia, high levels of serum inflammatory markers, and diffuse mature neutrophil infiltration typically localized to the upper dermis. Various drugs have been shown to be associated with Sweet syndrome. Bortezomib, a proteasome inhibitor approved for the treatment of multiple myeloma, has been reported to be associated with erythema, pruritus, eczemas, and, rarely, erythema multiforme-like skin changes or vasculitis. We describe a case involving a 65-year-old male who received bortezomib for the treatment of multiple myeloma. Over three cycles, multiple nodular lesions recurred through periods of aggravation and relief from symptoms. On the basis of the signs, symptoms, and biopsy results, the patient was diagnosed as showing Sweet syndrome. Skin lesions that occur during treatment of underlying disease can affect the patients’ treatment compliance. This case report indicates that a bortezomib rechallenge is an option for patients who develop sweet syndrome
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
En
مجلة:
Korean Journal of Dermatology
السنة:
2021
نوع:
Article