Host-Pathogen Interactions Operative during Mycobacteroides abscessus Infection
Immune Network
; : e40-2021.
Article
ي En
| WPRIM
| ID: wpr-914543
المكتبة المسؤولة:
WPRO
ABSTRACT
Mycobacteroides abscessus (previously Mycobacteroides abscessus; Mabc), one of rapidly growing nontuberculous mycobacteria (NTM), is an important pathogen of NTM pulmonary diseases (NTM-PDs) in both immunocompetent and immunocompromised individuals. Mabc infection is chronic and often challenging to treat due to drug resistance, motivating the development of new therapeutics. Despite this, there is a lack of understanding of the relationship between Mabc and the immune system. This review highlights recent progress in the molecular architecture of Mabc and host interactions. We discuss several microbial components that take advantage of host immune defenses, host defense pathways that can overcome Mabc pathogenesis, and how host-pathogen interactions determine the outcomes of Mabc infection. Understanding the molecular mechanisms underlying host-pathogen interactions during Mabc infection will enable the identification of biomarkers and/or drugs to control immune pathogenesis and protect against NTM infection.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
En
مجلة:
Immune Network
السنة:
2021
نوع:
Article