Deeper Understanding the Pathogenesis of Osteoarthritis from Matrix Viscoelasticity and Calcium Signaling / 医用生物力学
Journal of Medical Biomechanics
; (6): E001-E003, 2022.
Article
ي Zh
| WPRIM
| ID: wpr-920661
المكتبة المسؤولة:
WPRO
ABSTRACT
Generally, extracellular matrix (ECM) has the characteristics of viscoelasticity. In osteoarthritis (OA), catabolic processes alter the viscoelastic properties of functional pericellular matrix (PCM) of chondrocytes. Chondrocytes sense and respond to their mechanical microenvironment via an array of mechanosensitive receptors and channels that activate a complex network of downstream signaling pathways to regulate several cell processes central to OA pathology. Advances in understanding the specific mechanosignalling mechanisms in articular cartilage will promote the development of cell microenvironment construction in cartilage tissue engineering and the targeted precision therapeutics for OA. In this review, the work on the mechanism of matrix viscoelasticity regulating chondrocytes mechanotransduction by Agarwal et al. was briefly commented, and the recent advances related with their work was also discussed.
النص الكامل:
1
الفهرس:
WPRIM
نوع الدراسة:
Etiology_studies
اللغة:
Zh
مجلة:
Journal of Medical Biomechanics
السنة:
2022
نوع:
Article