Role of Vascular Aging in the Pathogenesis of Abdominal Aortic Aneurysm and Potential Therapeutic Targets / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 962-968, 2021.
Article
ي Zh
| WPRIM
| ID: wpr-921566
المكتبة المسؤولة:
WPRO
ABSTRACT
Abdominal aortic aneurysm(AAA)is a common aortic degenerative disease in the elderly,and its incidence is gradually increasing with the aging of the population.There are no specific drugs available to delay the expansion of AAA.Once the aneurysm ruptures,the mortality will exceed 90%,which seriously threatens the life of patients.Given the high incidence of AAA in the elderly,this review discusses the role of vascular aging in the pathogenesis of AAA,involving chronic inflammation,oxidative stress,mitochondrial dysfunction,protein homeostasis imbalance,increased apoptosis and necrosis,extracellular matrix remodeling,nutritional sensing disorders,epigenetic changes,and increased pro-aging factors.Meanwhile,several potential aging-related drug targets of AAA are listed.This review provides new ideas for basic and translational medical research of AAA.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Aorta, Abdominal
/
Aging
/
Aortic Aneurysm, Abdominal
/
Oxidative Stress
/
Disease Models, Animal
/
Muscle, Smooth, Vascular
نوع الدراسة:
Etiology_studies
/
Prognostic_studies
المحددات:
Animals
/
Humans
اللغة:
Zh
مجلة:
Acta Academiae Medicinae Sinicae
السنة:
2021
نوع:
Article