Recent advances of HIF-2α in pulmonary hypertension / 药学学报
Acta Pharmaceutica Sinica
; (12): 277-286, 2022.
Article
ي Zh
| WPRIM
| ID: wpr-922906
المكتبة المسؤولة:
WPRO
ABSTRACT
Pulmonary hypertension (PH) is a kind of disease characterized by progressive increase of pulmonary vascular resistance and occlusive vascular remodeling. Hypoxic inductive factor-2α (HIF-2α) plays an important role in the abnormal proliferation of pulmonary vascular cells and pulmonary vascular remodeling. This review focuses on the role of HIF-2α in pulmonary hypertension at the cellular and the global level, and candidates targeting HIF-2α for the treatment of pulmonary hypertension, in order to better understand the pathogenesis of PH and find effective treatments.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Acta Pharmaceutica Sinica
السنة:
2022
نوع:
Article