Progress in the Role of Mechanical Stimulus in Cardiac Development / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 164-172, 2022.
Article
ي Zh
| WPRIM
| ID: wpr-927861
المكتبة المسؤولة:
WPRO
ABSTRACT
Mechanical stimulus is critical to cardiovascular development during embryogenesis period.The mechanoreceptors of endocardial cells and cardiac myocytes may sense mechanical signals and initiate signal transduction that induce gene expression at a cellular level,and then translate molecular-level events into tissue-level deformations,thus guiding embryo development.This review summarizes the regulatory roles of mechanical signals in the early cardiac development including the formation of heart tube,looping,valve and septal morphogenesis,ventricular development and maturation.Further,we discuss the potential mechanical transduction mechanisms of platelet endothelial cell adhesion molecule 1-vascular endothelial-cadherin-vascular endothelial growth factor receptor 2 complex,primary cilia,ion channels,and other mechanical sensors that affect some cardiac malformations.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Myocytes, Cardiac
/
Mechanotransduction, Cellular
/
Vascular Endothelial Growth Factor A
/
Heart
المحددات:
Animals
/
Humans
اللغة:
Zh
مجلة:
Acta Academiae Medicinae Sinicae
السنة:
2022
نوع:
Article