A meta-analysis of the efficacy of biliary stent combined with radiofrequency ablation in the bile duct for malignant obstructive jaundice / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery
; (12): 932-937, 2021.
Article
ي Zh
| WPRIM
| ID: wpr-932721
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To systematically evaluate the clinical effect of biliary stent combined with intra-biliary radiofrequency ablation and stent alone in the treatment of malignant obstructive jaundice.Methods:
The PubMed, Cochrane library, Embase, HowNet, Wanfang, Weipu were systematically searched, the search time was up to February 2021. To collect and compare the clinical efficacy studies of combined intra-biliary radiofrequency ablation in the treatment of patients with malignant obstructive jaundice before biliary stent placement. After literature screening, data extraction and quality assessment conducted by two independent reviewers. Meta-analysis was performed with the patients' 1-year survival rate, 6-month patency rate after biliary stent operation, and comparative changes in postoperative complications as the main outcome indicators.Results:
Finally, 9 studies were included, comprising 2 randomized controlled studies (RCT) and 7 retrospective studies, involving a total of 443 patients, with 211 cases in the biliary stent combined with intra-biliary radiofrequency ablation group and 232 cases in the stent alone group. The results of meta-analysis showed that in two joint groups compared with the stent alone group, in overall analysis, the rate of re-obstruction of the biliary tract decreased 6 months after stenting ( OR=0.24, 95% CI 0.13-0.42) and 1-year survival rate increased ( OR=3.79, 95% CI 2.08-6.90), the differences are statistically significant ( P<0.001), there was no statistical difference in the complications ( P=0.13). In ERCP group, the rate of re-obstruction of the biliary tract decreased 6 months after stenting ( OR=0.21, 95% CI 0.08-0.55), and the 1-year survival rate significant increase ( OR=3.63, 95% CI 1.76-7.48), the differences are statistically significant ( P<0.01). In PTCD group, the rate of re-obstruction of the biliary tract decreased 6 months after stenting ( OR=0.25, 95% CI 0.12-0.51), and the 1-year survival rate significant increase ( OR=4.13, 95% CI 1.42-12.03), the differences are statistically significant ( P<0.01).Conclusion:
Compared with the stent-only group, the combined group is safe and effective in treating malignant obstructive jaundice.
النص الكامل:
1
الفهرس:
WPRIM
نوع الدراسة:
Clinical_trials
/
Observational_studies
/
Systematic_reviews
اللغة:
Zh
مجلة:
Chinese Journal of Hepatobiliary Surgery
السنة:
2021
نوع:
Article