Role of eosinophil extracellular traps in the pathogenesis of chronic airway diseases / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 241-244, 2022.
Article
ي Zh
| WPRIM
| ID: wpr-934038
المكتبة المسؤولة:
WPRO
ABSTRACT
Eosinophil extracellular traps (EETs), an important pathway of eosinophil to exert its effects, are composed of DNA fibers, histone and eosinophil granule proteins. Recently, many researches have shown that EETs play an important role in the genesis and development of respiratory diseases including asthma, allergic bronchopulmonary aspergillosis and chronic obstructive pulmonary disease. EETs can directly damage airway epithelial cells, promote airway inflammation and airway hypersecretion, increase the stickiness of secretions and induce the generation of autoantibody, helping eosinophils and their products participate in a cascade of events leading to inflammation and disease. Researches on EETs can also be helpful in investigating new targets for the treatment of chronic airway diseases.
النص الكامل:
1
الفهرس:
WPRIM
نوع الدراسة:
Etiology_studies
اللغة:
Zh
مجلة:
Chinese Journal of Microbiology and Immunology
السنة:
2022
نوع:
Article