Effect of ulinastatin combined rivaroxaban on deep vein thrombosis in major orthopedic surgery
Asian Pacific Journal of Tropical Medicine
; (12): 918-921, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-951799
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective:
To explore the effect of ulinastatin (UTI) continuous infusion combined Rivaroxaban on the deep vein thrombosis in patients undergoing major orthopedic surgery.Methods:
Forty-five patients undergoing major orthopedic surgery were randomly divided into three groupsulinastatin continuous infusion (Uc) group, ulinastatin single injection (Us) group and control (C) group. All patients received patient-controlled intravenous analgesia (PCIA) after operation, and took Rivaroxaban 10 mg orally 12 hours after operation. Ulinastatin (5 000 U/kg) was given intravenously to both Uc and Us groups preoperatively. Group C was given isometric normal saline, group Uc was pumped UTI continuous intravenously at the end of surgery (10 000 U/kg) to 48 hours through PCIA pump. The values of hematocrit (HCT), thrombomodulin (TM), Interleukin (IL-6), thrombin-antithrombin complex (TAT), D-Dimer (D-D) were normally tested before surgery (T1), at the end of the surgery (T2), 12 hours (T3), 24 hours (T4) and 48 hours (T5) after surgery.Results:
Compared with T1, there was an upward tendency in TM, IL-6, TAT, and D-D after operation in group C group (. P0.05).Conclusions:
During the perioperative period, ulinastatin continuous infusion combined Rivaroxaban can correct blood hypercoagulability through different approaches in patients undergoing major orthopedic surgery.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Asian Pacific Journal of Tropical Medicine
السنة:
2014
نوع:
Article