Cerebral salt-wasting syndrome after hematopoietic stem cell transplantation in adolescents: 3 case reports
Annals of Pediatric Endocrinology & Metabolism
; : 220-225, 2015.
Article
ي En
| WPRIM
| ID: wpr-96137
المكتبة المسؤولة:
WPRO
ABSTRACT
Cerebral salt-wasting syndrome (CSWS) is a rare disease characterized by a extracellular volume depletion and hyponatremia induced by marked natriuresis. It is mainly reported in patients who experience a central nervous system insult, such as cerebral hemorrhage or encephalitis. The syndrome of inappropriate antidiuretic hormone secretion is a main cause of severe hyponatremia after hematopoietic stem cell transplantation, whereas CSWS is rarely reported. We report 3 patients with childhood acute leukemia who developed CSWS with central nervous system complication after hematopoietic stem cell transplantation. The diagnosis of CSW was made on the basis of severe hyponatremia accompanied by increased urine output with clinical signs of dehydration. All patients showed elevated natriuretic peptide and normal antidiuretic hormone. Aggressive water and sodium replacement treatment was instituted in all 3 patients and 2 of them were effectively recovered, the other one was required to add fludrocortisone administration.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Polyuria
/
Sodium
/
Fludrocortisone
/
Hematopoietic Stem Cells
/
Water
/
Leukemia
/
Central Nervous System
/
Cerebral Hemorrhage
/
Hematopoietic Stem Cell Transplantation
/
Dehydration
نوع الدراسة:
Diagnostic_studies
المحددات:
Humans
اللغة:
En
مجلة:
Annals of Pediatric Endocrinology & Metabolism
السنة:
2015
نوع:
Article