Role and mechanism of hydrogen sulfide in vascular calcification / 生理学报
Acta Physiologica Sinica
; (6): 903-912, 2022.
Article
ي Zh
| WPRIM
| ID: wpr-970086
المكتبة المسؤولة:
WPRO
ABSTRACT
Vascular calcification is a common pathological process in patients with diabetes, chronic kidney disease, and cardiovascular disease, manifested by the deposition of hydroxyapatite on the walls of blood vessels. Hydrogen sulfide is the third gas signal molecule found in mammals after nitric oxide and carbon monoxide, which has anti-inflammatory, antioxidant stress and other effects in the cardiovascular system. In recent years, it has been recognized that hydrogen sulfide has an anti-vascular calcification effect, and supplementation with hydrogen sulfide and its donors can alleviate vascular calcification. In this review, we discussed the various evidence of the protective effect of hydrogen sulfide on vascular calcification, and highlighted the hydrogen sulfide metabolism changes and the potential regulatory mechanisms of hydrogen sulfide on the pathophysiological changes in vascular calcification.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Carbon Monoxide
/
Cardiovascular Diseases
/
Hydrogen Sulfide
/
Mammals
/
Nitric Oxide
/
Antioxidants
المحددات:
Animals
/
Humans
اللغة:
Zh
مجلة:
Acta Physiologica Sinica
السنة:
2022
نوع:
Article