Advances in epigenetic regulation of Chinese hamster ovary cells / 生物工程学报
Chinese Journal of Biotechnology
; (12): 149-158, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-970365
المكتبة المسؤولة:
WPRO
ABSTRACT
Chinese hamster ovary (CHO) cells play an irreplaceable role in biopharmaceuticals because the cells can be adapted to grow in suspension cultures and are capable of producing high quality biologics exhibiting human-like post-translational modifications. However, gene expression regulation such as transgene silencing and epigenetic modifications may reduce the recombinant protein production due to the decrease of expression stability of CHO cells. This paper summarized the role of epigenetic modifications in CHO cells, including DNA methylation, histone modification and miRNA, as well as their effects on gene expression regulation.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Recombinant Proteins
/
Gene Expression Regulation
/
Cricetulus
/
CHO Cells
/
DNA Methylation
/
Epigenesis, Genetic
المحددات:
Animals
/
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Biotechnology
السنة:
2023
نوع:
Article