Research advances on the mechanism of Wnt/β-catenin signaling pathway in body surface wound healing / 中华烧伤杂志
Chinese Journal of Burns
; (6): 190-195, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-971169
المكتبة المسؤولة:
WPRO
ABSTRACT
Wound healing is a slow and complex biological process, including inflammatory reaction, cell proliferation, cell differentiation, cell migration, angiogenesis, extracellular matrix deposition, tissue remodeling, and so on. Wnt signaling pathway can be divided into classical pathway and non-classical pathway. Wnt classical pathway, also known as Wnt/β-catenin signaling pathway, plays an important role in cell differentiation, cell migration, and maintenance of tissue homeostasis. Many inflammatory factors and growth factors are involved in the upstream regulation of this pathway. The activation of Wnt/β-catenin signaling pathway plays an important role in the occurrence, development, regeneration, repair and related treatment of skin wounds. This article review the relationship between Wnt/β-catenin signaling pathway and wound healing, meanwhile summarizes its effects on important processes of wound healing, such as inflammation, cell proliferation, angiogenesis, hair follicle regeneration, and skin fibrosis, as well as the role of inhibitors of Wnt signaling pathway in wound healing.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Wound Healing
/
Cell Differentiation
/
Cell Movement
/
Cell Proliferation
/
Wnt Signaling Pathway
/
Inflammation
المحددات:
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Burns
السنة:
2023
نوع:
Article