Chinese expert consensus on transanal drug administration for constipation (2022 edition ) / 中华胃肠外科杂志

ABSTRACT

Constipation is a clinical symptom. It can be caused by environment, habit, disease and drugs. Chronic constipation is a disease that can occur at any age and its prevalence increases with age. Transanal administration is a common method to treat all kinds of constipation, especially to relieve stool blockage. However, the method and dose of transanal administration vary by age, drug and preparation types of drugs, and the effect of defecation is also quite different. At present, there is no expert consensus to follow in China or abroad. This consensus was convened by Anorectal Branch of Chinese Medical Doctor Association, Colorectal Surgery Group of Branch of Surgery of Chinese Medical Association and Chinese Journal of Gastrointestinal Surgery, to incorporate the latest evidence in China and abroad. This consensus addressed common transanal preparations, principles of administration, and efficacy for constipation. The evidence quality was assessed and the recommendation intensity was graded according to the GRADE system. The consensus aims to help standardize drug selection in practice and guide clinical application.