Role of mucociliary clearance system in respiratory diseases / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 275-284, 2023.
Article
ي En
| WPRIM
| ID: wpr-971395
المكتبة المسؤولة:
WPRO
ABSTRACT
Mucociliary clearance system is the primary innate defense mechanism of the lung. It plays a vital role in protecting airways from microbes and irritants infection. Mucociliary clearance system, which is mediated by the actions of airway and submucosal gland epithelial cells, plays a critical role in a multilayered defense system via secreting fluids, electrolytes, antimicrobial and anti-inflammatory proteins, and mucus onto airway surfaces. Changes in environment, drugs or diseases can lead to mucus overproduction and cilia dysfunction, which in turn decrease the rate of mucociliary clearance and enhance mucus gathering. The dysfunction of mucociliary clearance system often occurs in several respiratory diseases, such as primary ciliary dysfunction, cystic fibrosis, asthma and chronic obstructive pulmonary disease, which are characterized by goblet cell metaplasia, submucosal gland cell hypertrophy, mucus hypersecretion, cilia adhesion, lodging and loss, and airway obstruction.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Respiratory System
/
Respiratory Tract Diseases
/
Mucociliary Clearance
/
Pulmonary Disease, Chronic Obstructive
/
Lung
/
Mucus
المحددات:
Humans
اللغة:
En
مجلة:
Journal of Central South University(Medical Sciences)
السنة:
2023
نوع:
Article