Anti-inflammatory sesquiterpene polyol esters from the stem and branch of Tripterygium wilfordii / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 233-240, 2023.
Article
ي En
| WPRIM
| ID: wpr-971681
المكتبة المسؤولة:
WPRO
ABSTRACT
The stem and branch extract of Tripterygium wilfordii (Celastraceae) afforded seven new dihydroagarofuran sesquiterpene polyesters [tripterysines A-G (1-7)] and eight known ones (8-15). The chemical structures of these new compounds were established based on combinational analysis of HR-ESI-MS and NMR techniques. The absolute configurations of tripterysines A-C (1-3) and E-G (5-7) were determined by X-ray crystallographic analysis and circular dichroism spectra. All the compounds were screened for their inhibitory effect on inflammation through determining their inhibitory effect on nitric oxide production in LPS-induced RAW 264.7 cells and the secretion of inflammatory cytokines TNF-α and IL-6 in LPS-induced BV2 macrophages. Compound 9 exhibited significant inhibitory activity on NO production with an IC50 value of 8.77 μmol·L-1. Moreover, compound 7 showed the strongest inhibitory effect with the secretion of IL-6 at 27.36%.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Sesquiterpenes
/
Molecular Structure
/
Lipopolysaccharides
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Interleukin-6
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Plant Leaves
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Tripterygium
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Esters
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Anti-Inflammatory Agents
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Nitric Oxide
اللغة:
En
مجلة:
Chinese Journal of Natural Medicines (English Ed.)
السنة:
2023
نوع:
Article