Research Progress of NK Cells in Immunotherapy of Glioma / 中山大学学报(医学科学版)
Journal of Sun Yat-sen University(Medical Sciences)
; (6): 511-518, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-973250
المكتبة المسؤولة:
WPRO
ABSTRACT
Natural Killer (NK) cells are another type of anti-tumor immune cells with promising clinical application in addition to T cells. NK cell activity is mainly regulated by its surface receptors and immune microenvironment. The strong immunosuppressive microenvironment of glioma results in low efficiency of NK cell immunotherapy. This article reviews NK cells in the immunotherapy for glioma from the interaction of glioma-NK cell, and the latest research progress of targeted NK cells compounds, monoclonal antibody, and cytokine therapy, focusing on the genetic modification of NK cells in the present situation and trend of glioma immunotherapy, and molecular mechanism of glioma cells related to immune escape. We hope this article will provide theoretical basis and new ideas for NK cell-based immunotherapy of glioma.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of Sun Yat-sen University(Medical Sciences)
السنة:
2023
نوع:
Article