Role of Histone Modifications and 12/15-lipoxygenase Metabolic Pathway in the Development of Diabetic Kidney Disease / 中山大学学报(医学科学版)
Journal of Sun Yat-sen University(Medical Sciences)
; (6): 534-540, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-973253
المكتبة المسؤولة:
WPRO
ABSTRACT
Diabetic kidney disease (DKD) is one of the most common microvascular complications in patients with diabetes. DKD is also the main cause of end-stage renal failure, with very complex pathogenesis. A large number of experiments have confirmed that epigenetic mechanisms, including histone chemical modifications and lipid metabolites 12/15-lipoxygenase (12/15-LO), are involved in regulating the characteristic pathophysiological process of DKD, based on which, this review further explores the pathogenesis of DKD and provides the new research direction for DKD treatment.
النص الكامل:
1
الفهرس:
WPRIM
اللغة:
Zh
مجلة:
Journal of Sun Yat-sen University(Medical Sciences)
السنة:
2023
نوع:
Article