SGK1 as a therapeutic target for central nervous system diseases / 生理学报
Acta Physiologica Sinica
; (6): 451-464, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-981020
المكتبة المسؤولة:
WPRO
ABSTRACT
Serum and glucocorticoid-regulated kinase 1 (SGK1) plays an important role in the physiological processes of hormone release, neuronal excitation and cell proliferation. SGK1 also participates in the pathophysiological processes of inflammation and apoptosis in the central nervous system (CNS). Increasing evidence demonstrates that SGK1 may serve as a target of the intervention of neurodegenerative diseases. In this article, we summarize the recent progress on the role and molecular mechanisms of SGK1 in the regulation of the function of the CNS. We also discuss the potential of newly discovered SGK1 inhibitors in the treatment of CNS diseases.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Central Nervous System Diseases
/
Protein Serine-Threonine Kinases
/
Cell Proliferation
/
Inflammation
المحددات:
Humans
اللغة:
Zh
مجلة:
Acta Physiologica Sinica
السنة:
2023
نوع:
Article