Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 501-509, 2023.
Article
ي En
| WPRIM
| ID: wpr-981080
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline (BR) and the conventional treatment regimen (CR, not containing Bedaquiline) for the treatment of adults with multidrug-resistant tuberculosis (MDR-TB) in China.@*METHODS@#A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years. The model parameter data were synthesized from the literature, the national TB surveillance information system, and consultation with experts. The incremental cost-effectiveness ratio (ICER) of BR vs. CR was determined.@*RESULTS@#BR ( vs. CR) had a higher sputum culture conversion rate and cure rate and prevented many premature deaths (decreased by 12.8%), thereby obtaining more quality-adjusted life years (QALYs) (increased by 2.31 years). The per capita cost in BR was as high as 138,000 yuan, roughly double that of CR. The ICER for BR was 33,700 yuan/QALY, which was lower than China's 1× per capita Gross Domestic Product (GDP) in 2020 (72,400 yuan).@*CONCLUSION@#BR is shown to be cost effective. When the unit price of Bedaquiline reaches or falls below 57.21 yuan per unit, BR is expected to be the dominant strategy in China over CR.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
China
/
Cost-Benefit Analysis
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Tuberculosis, Multidrug-Resistant
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Cost-Effectiveness Analysis
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Antitubercular Agents
المحددات:
Adult
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Humans
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Biomedical and Environmental Sciences
السنة:
2023
نوع:
Article