Chemical constituents from Paris rugosa rhizomes and their antimicrobial activities / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2981-2988, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-981430
المكتبة المسؤولة:
WPRO
ABSTRACT
Paris rugosa(Melanthiaceae) only grows in Yunnan province of China at present, and its chemical constituents have not been systematically studied. In this study, nine compounds, including one new compound pariposide G(1) and eight known compounds of cerin(2), stigmast-4-en-3-one(3), β-ecdysone(4), ophiopogonin C'(5), methyl protogracillin(6), gracillin(7), parissaponin H(8), and parisyunnanoside G(9), were isolated and identified from the ethanol extract of P. rugosa rhizomes by column chromatography methods and semi-preparative high-performance liquid chromatography(HPLC). Compounds 1-9 were isolated from this plant for the first time. The antibacterial and antifungal activities of all the compounds were evaluated. The results showed that ophiopogonin C' had strong inhibitory effects on Candida albicans [MIC_(90)=(4.68±0.01) μmol·L~(-1)] and the fluconazole-resistant strain of C. albicans [MIC_(90)=(4.66±0.02) μmol·L~(-1)].
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Candida albicans
/
China
/
Liliaceae
/
Rhizome
/
Melanthiaceae
/
Anti-Bacterial Agents
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2023
نوع:
Article