Methcathinone Increases Visually-evoked Neuronal Activity and Enhances Sensory Processing Efficiency in Mice / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 602-616, 2023.
Article
ي En
| WPRIM
| ID: wpr-982426
المكتبة المسؤولة:
WPRO
ABSTRACT
Methcathinone (MCAT) belongs to the designer drugs called synthetic cathinones, which are abused worldwide for recreational purposes. It has strong stimulant effects, including enhanced euphoria, sensation, alertness, and empathy. However, little is known about how MCAT modulates neuronal activity in vivo. Here, we evaluated the effect of MCAT on neuronal activity with a series of functional approaches. C-Fos immunostaining showed that MCAT increased the number of activated neurons by 6-fold, especially in sensory and motor cortices, striatum, and midbrain motor nuclei. In vivo single-unit recording and two-photon Ca2+ imaging revealed that a large proportion of neurons increased spiking activity upon MCAT administration. Notably, MCAT induced a strong de-correlation of population activity and increased trial-to-trial reliability, specifically during a natural movie stimulus. It improved the information-processing efficiency by enhancing the single-neuron coding capacity, suggesting a cortical network mechanism of the enhanced perception produced by psychoactive stimulants.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Perception
/
Sensation
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Reproducibility of Results
/
Neurons
المحددات:
Animals
اللغة:
En
مجلة:
Neuroscience Bulletin
السنة:
2023
نوع:
Article