The study on expression of NF-kappaB in experimental brain contusion in rats / 法医学杂志
Journal of Forensic Medicine
; (6): 73-80, 2004.
Article
ي Zh
| WPRIM
| ID: wpr-983019
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of NF-kappaB in different post-traumatic intervals and severity of brain injury.@*METHODS@#Fifty-four brain tissue samples of slight (n=24), moderate (n=24) brain injury, sham (n=3) and control (n=3) of rat were examined by immunohistochemical staining, westernblot and RT-PCR.@*RESULTS@#Up-regulating of NF-kappaB expression was found in tissues from traumatic brain injury compared with controls in early 1 hour after TBI, and reached peak at 24h and 48h and disappeared after 7 days. The expression of NF-kappaB mRNA has association with contusion severity.@*CONCLUSION@#NF-kappaB may benefit to the estimation of posttraumatic intervals of brain injury.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Staining and Labeling
/
Time Factors
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Brain Injuries
/
RNA, Messenger
/
Immunohistochemistry
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Injury Severity Score
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Blotting, Western
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NF-kappa B
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Reverse Transcriptase Polymerase Chain Reaction
المحددات:
Animals
اللغة:
Zh
مجلة:
Journal of Forensic Medicine
السنة:
2004
نوع:
Article