The expression of VCAM-1 in organs of rats died of anaphylactic shock / 法医学杂志
Journal of Forensic Medicine
; (6): 87-90, 2011.
Article
ي Zh
| WPRIM
| ID: wpr-983629
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect and expression of the vascular cell adhesion molecule-1 (VCAM-1) in organs of rats died of anaphylactic shock.@*METHODS@#The models of anaphylactic shock in rats were made and the immunohistochemistry of SABC was used to detect as follows: (1) The expression of VCAM-1 in rat lung, heart, brain, kidney, liver, spleen, stomach and intestine. (2) VCAM-1 levels in lungs at 10 min, 30 min after the allergic shock, and the time of death. (3) VCAM-1 levels in lungs of rats after the intervention of anti-VCAM-1.@*RESULTS@#After the death, the expression VCAM-1 in lungs increased significantly relative to the control group and followed the extension of shock. In the rats which were injected with the anti-VCAM-1, the expression of VCAM-1 in lungs reduced.@*CONCLUSION@#(1) The expression of VCAM-1 shows difference in the various organs of rats after anaphylactic shock. The change of VCAM-1 is the most obvious in lungs and would increase followed the extension of anaphylactic shock. (2) After the anaphylactic shock, anti-VCAM-1 can inhibit the expression of VCAM-1 in rat lung.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Time Factors
/
Brain
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Immunohistochemistry
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Random Allocation
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Rats, Sprague-Dawley
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Vascular Cell Adhesion Molecule-1
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Disease Models, Animal
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Anaphylaxis
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Kidney
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Lung
المحددات:
Animals
اللغة:
Zh
مجلة:
Journal of Forensic Medicine
السنة:
2011
نوع:
Article