Expression of CaMK II delta in cerebral cortex following traumatic brain injury / 法医学杂志
Journal of Forensic Medicine
; (6): 169-177, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-983899
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVE@#To observe the time-course expression of calcium-calmodulin dependent protein kinase II delta (CaMK II delta) in cerebral cortex after traumatic brain injury (TBI).@*METHODS@#The TBI rat model was established. The expression of CaMK II delta in cerebral cortex around injured area was tested by Western blotting and immunohistochemical staining.@*RESULTS@#Western blotting revealed expression of CaMK II delta in normal rat brain cortex. It gradually increased after TBI, peaked after 3 days, and then returned to normal level. The result of immunohistochemical staining was consistent with that of Western blotting.@*CONCLUSION@#The expression of CaMK II delta around injured area after TBI increased initially and then decreased. It could be used as a new indicator for wound age determination following TBI.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Time Factors
/
Brain Injuries
/
Immunohistochemistry
/
Cerebral Cortex
/
Blotting, Western
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
/
Forensic Medicine
المحددات:
Animals
اللغة:
Zh
مجلة:
Journal of Forensic Medicine
السنة:
2014
نوع:
Article