Incidence and Risk Factors of Tuberculosis in Patients with Human Immunodeficiency Virus Infection
Journal of Korean Medical Science
; : 374-377, 2013.
Article
ي En
| WPRIM
| ID: wpr-98491
المكتبة المسؤولة:
WPRO
ABSTRACT
Korea is a low prevalence country for human immunodeficiency virus (HIV) infection and has an intermediate tuberculosis (TB) burden. We previously reported that the incidence of TB in HIV-infected patients was 9.6 cases per 100 person-years (P-Y) between 1988 and 1997. The aims of the present study were to measure any change in incidence from the previous study, and to identify risk factors for TB in HIV-infected patients. We reviewed all medical records of HIV-infected patients who were followed-up in one tertiary hospital between 1998 and 2010. Over the total observation period of 5858.33 P-Y, TB developed in 70 patients (1.19 cases per 100 P-Y; 95% confidence interval [CI], 0.91-1.47 cases per 100 P-Y). Based on Poisson regression, one risk factor associated with TB was an initial CD4+ cell count below 200 cells/microliter (relative risk, 2.34; 95% CI, 1.47-3.73). Mean CD4+ cell counts of pulmonary, extrapulmonary, and both pulmonary and extrapulmonary TB were 179.8 cells/microliter, 138.3 cells/microliter, and 114.2 cells/microliter, respectively (P = 0.55). In conclusion, the incidence of TB in HIV-infected patients has decreased since the previous study. An initial CD4+ cell count below 200 cells/microliter is an independent risk factor for development of TB in HIV-infected patients.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Tuberculosis
/
HIV Infections
/
Incidence
/
Retrospective Studies
/
Risk Factors
/
CD4 Lymphocyte Count
نوع الدراسة:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Adult
/
Female
/
Humans
/
Male
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2013
نوع:
Article