The research of liver failure in Banna miniature pigs caused by amanita exitialis / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 443-447, 2023.
Article
ي Zh
| WPRIM
| ID: wpr-986047
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective: To explore the characteristics of Banna miniature pig liver failure induced by amanita exitialis. Methods: From September to October 2020, a reverse high performance liquid chromatography (RP-HPLC) method was used to determine the toxin content of amanita exitialis solution, and 2.0 mg/kg amanita exitialis solution (α-amanitins+β-amanitins) was administered orally to Banna miniature pigs. Toxic symptoms, blood biochemical indexes and histopathological changes of liver, heart and kidney were observed at each time point. Results: All Banna miniature pigs died within 76 h of exposure, and different degrees of digestive tract symptoms such as nausea, vomiting and diarrhea appeared between 6 and 36 h. The biochemical indexes of alanine aminotransferase, aspartate aminotransferase, total bilirubin, lactate dehydrogenase, myoglobin, creatine kinase isoenzyme, blood urea nitrogen and creatinine increased significantly at 52 h after exposure, and the differences were statistically significant compared with 0 h (P<0.05). The bleeding of liver and heart was obvious under macroscopic and microscopic observation, hepatocyte necrosis, renal tubule epithelial cell swelling. Conclusion: Large dose of amanita exitialis can cause acute liver failure of Banna miniature pigs, which is in line with the pathophysiological characteristics of acute liver failure, and lays a foundation for further research on the toxic mechanism and detoxification drugs of amanita exitialis induced liver failure.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Swine
/
Swine, Miniature
/
Mushroom Poisoning
/
Liver Failure, Acute
/
Amanitins
/
Amanita
المحددات:
Animals
اللغة:
Zh
مجلة:
Chinese Journal of Industrial Hygiene and Occupational Diseases
السنة:
2023
نوع:
Article