The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice
Yonsei Medical Journal
; : 97-103, 1996.
Article
ي En
| WPRIM
| ID: wpr-99934
المكتبة المسؤولة:
WPRO
ABSTRACT
Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Seizures
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Body Temperature
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Receptors, Histamine H1
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Receptors, Histamine H2
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P-Methoxy-N-methylphenethylamine
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Animals
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Hypoxia
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Mice, Inbred BALB C
المحددات:
Animals
اللغة:
En
مجلة:
Yonsei Medical Journal
السنة:
1996
نوع:
Article