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The efficacy of two doses versus 7 days' course of prophylactic antibiotics following cesarean section: An experience from Aminu Kano Teaching Hospital
Annals of African Medicine ; 19(2), p.103-112 , tab., 2020
Article in English | AIM (Africa) | ID: afr-201963
Responsible library: CG1.1
ABSTRACT
Postcesarean wound infection is a leading cause of prolonged hospital stay. Considerable debates still exist regarding choice of antibiotics, dose, and duration of use.

Objectives:

The objective is to compare the efficacy of 2 doses of amoxicillin-clavulanic acid versus a 7 days combination of amoxicillin-clavulanic acid and metronidazole as prophylactic antibiotics following cesarean section (CS).

Methodology:

It was a randomized controlled trial that was conducted among 160 women undergoing CS at Aminu Kano Teaching Hospital. Women were randomized into two groups. Group I (study group) received 2 doses of 1.2 g amoxicillin-clavulanic acid. Group II (control group) received a 7 days course of amoxicillin-clavulanic acid and metronidazole. The data obtained were analyzed using SPSS version 17. Categorical (qualitative) variables were analyzed using Chi-square test and Fisher's exact test as appropriate while continuous (quantitative) variables were analyzed using independent sample t-test. P < 0.05 was considered statistically significant.

Results:

There was no statistically significant association in the occurrence of fever (12.8% vs. 15.8%, P = 0.6), wound infection (6.4% vs. 10.5%, P = 0.36), endometritis (7.7% vs. 11.8%, P = 0.38), UTI (6.4% vs. 5.3%, P = 1.00), mean duration of hospital stay (129.7 vs. 134.2 h, P = 0.48), and neonatal outcomes between the two groups. There was statistically significant difference in the mean cost of antibiotics (₦2883/US$9.5 vs. ₦7040/US$23.1, P < 0.001) and maternal side effects (10.3% vs. 26.3%, P < 0.001) between the study and the control groups, respectively.

Conclusion:

This study found no statistically significant difference in infectious morbidity, duration of hospital stay, and neonatal outcomes when two doses of amoxicillin-clavulanic acid was compared with a 7 days course of prophylactic antibiotic following CS. The use of two doses of amoxicillin-clavulanic acid has the advantages of reduced cost and some maternal side effects. The two doses were cheaper with minimal side effects.
Subject(s)
Full text: Available Index: AIM (Africa) Main subject: Potassium / Morbidity / Clavulanic Acid / Amoxicillin / Methods / Nigeria Type of study: Controlled clinical trial / Observational_studies / Qualitative_research Country/Region as subject: Africa Language: English Journal: Annals of African Medicine Year: 2020 Type: Article

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Full text: Available Index: AIM (Africa) Main subject: Potassium / Morbidity / Clavulanic Acid / Amoxicillin / Methods / Nigeria Type of study: Controlled clinical trial / Observational_studies / Qualitative_research Country/Region as subject: Africa Language: English Journal: Annals of African Medicine Year: 2020 Type: Article