Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats
Acta cir. bras
;
34(7): e201900706, 2019. tab, graf
Article
in English
| LILACS
| ID: biblio-1038113
ABSTRACT
Abstract Purpose:
To investigate the protective roles of pyracantha fortune fruit extract (PFE) on acute renal toxicity induced by cadmium chloride (CdCl2) in rats.Methods:
Rats were pretreated with PFE and consecutively injected with CdCl2 (6.5 mg/kg) for 5 days.Results:
The concentration of Cd, kidney weight, malondialdehyde (MDA), and nitric oxide (NO) production were remarkably increased in CdCl2 group as well as the levels of plasma uric acid, urea, and creatinine (P < 0.001). However, the body weight and glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione peroxidase (GR) levels were markedly reduced by CdCl2 treatment (P < 0.001). Histological manifestations of renal tissue showed severely adverse changes. Moreover, CdCl2 treatment significantly decreased the B-cell lymphoma-2 (Bcl-2) expression while increased the Bcl-2-Associated X Protein (Bax), tumor necrosis factor-α (TNF-α) expression (P < 0.001). Additionally, the expression of Nrf2/Keap 1 related proteins Keap-1 gained a significant increase (P < 0.001), whereas the Nrf2, HO-1, γ-GCS, GSH-Px and NQO1 expression decreased by CdCl2 treatment (P < 0.05). These rats were pretreated with PFE to improve the changes caused by CdCl2 treatment.Conclusion:
PFE could protect the kidney against acute renal toxicity induced by CdCl2.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Plant Extracts
/
Cadmium Chloride
/
Pyracantha
/
Chemical and Drug Induced Liver Injury
/
Kidney
/
Antioxidants
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Type:
Article
Affiliation country:
China
Institution/Affiliation country:
Wenzhou Medical University/CN
Similar
MEDLINE
...
LILACS
LIS