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Steatosis and steatohepatitis found in adults after death due to non-burn trauma
Reis-Júnior, Paulo; Tanigawa, Ryan; de Mesquita, Gustavo Heluani Antunes; Basan, Natalia; Alves, Venâncio; D'Albuquerque, Luiz Augusto Carneiro; Andraus, Wellington.
  • Reis-Júnior, Paulo; Universidade Federal do Tocantins. Faculdade de Medicina. Palmas. BR
  • Tanigawa, Ryan; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Divisao de Patologia. Sao Paulo. BR
  • de Mesquita, Gustavo Heluani Antunes; Universidade de Sao Paulo. Faculdade de Medicina FMUSP. Sao Paulo. BR
  • Basan, Natalia; Universidade Federal do Tocantins. Faculdade de Medicina. Palmas. BR
  • Alves, Venâncio; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Divisao de Patologia. Sao Paulo. BR
  • D'Albuquerque, Luiz Augusto Carneiro; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo. Departamento de Gastroenterologia. São Paulo. BR
  • Andraus, Wellington; Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo. Servico de Transplante e Cirurgia do Figado. Sao Paulo. BR
Clinics ; 74: e1070, 2019. tab, graf
Article in English | LILACS | ID: biblio-1039540
ABSTRACT

OBJECTIVE:

With the increasing prevalence of steatosis, the number of steatotic liver grafts from deceased donors is also increasing. Thus, determining the prevalence and the population risk factors of steatosis may assist in risk stratification. The aim of this study was to evaluate the prevalence and predictors of steatosis and steatohepatitis among livers from adults who died due to non-burn trauma.

METHODS:

Specimens were collected from 224 adults undergoing autopsy at a regional autopsy referral center from September 2011 to April 2013. Histopathological examination was performed on six samples obtained from different lobes of each liver. The outcomes of interest were the presence of steatosis, steatohepatitis, NASH inflammation and NASH fibrosis. The main predictors were body mass index, abdominal circumference, liver weight and volume, presence of cholelithiasis, and siderosis. Our modeling strategy made use of a series of generalized linear models with a binomial family.

RESULTS:

Our sample had a mean age of 40 years; steatosis was diagnosed in 48.2% of cases, and steatohepatitis was diagnosed in 2.7%. The presence of a high proportion of fatty changes was more prevalent among males and older individuals, with the most affected age group being 41-60 years. When evaluating the crude odds ratio for steatosis, the factors significantly associated with an increased risk of steatosis were greater abdominal circumference, BMI, and liver weight and the presence of siderosis.

CONCLUSION:

Our study reinforces the role of older age, obesity and hepatomegaly as predictors of fatty liver disease. These variables should be considered in the assessment of fatty changes in the livers of potential liver donors.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Fatty Liver Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR / Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo/BR / Universidade Federal do Tocantins/BR

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Full text: Available Index: LILACS (Americas) Main subject: Fatty Liver Type of study: Etiology study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2019 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo/BR / Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo/BR / Universidade Federal do Tocantins/BR